A Comparison of Induction-Detection NMR and Force- Detection NMR on Micro-NMR Device Design
نویسندگان
چکیده
Nuclear Magnetic Resonance (NMR) is widely used in medical diagnostics and chemical analysis. Due to rapid growing of the NMR applications, the conventional NMR systems may not fulfill the need of all applications. The development of a micro-NMR device would not only benefit the original NMR applications but could also open a door for new NMR applications. Two approaches for building a NMR system, Induction-Detection Nuclear Magnetic Resonance (IDNMR) and Force-Detection Nuclear Magnetic Resonance (FDNMR) are explored and compared in this paper. The comparison result shows that the FDNMR approach outperforms the IDNMR approach in signal-to-noise ratio when the sample radius is below 410 μm for protons and 1900 μm for chlorides. This suggests that the FDNMR approach is more appropriate for making the micro-NMR device.
منابع مشابه
Development of an NMR interface microchip "MICCS" for direct detection of reaction products and intermediates of micro-syntheses using a "MICCS-NMR".
The development of an NMR interface microchip and its applications to the real-time monitoring of chemical reactions are described. The microchip device was named "MICCS" (MIcro Channeled Cell for Synthesis monitoring), and the method using it was named "MICCS-NMR". MICCS was inserted into a 5 mm Phi NMR sample tube. Thus standard solution NMR probes without any modifications can be used in MIC...
متن کاملNMR analysis on microfluidic devices by remote detection.
We present a novel approach to perform high-sensitivity NMR imaging and spectroscopic analysis on microfluidic devices. The application of NMR, the most information-rich spectroscopic technique, to microfluidic devices remains a challenge because the inherently low sensitivity of NMR is aggravated by small fluid volumes leading to low NMR signal and geometric constraints resulting in poor effic...
متن کاملIterative Force-Field Calculation and Molecular Dynamics of Cyclooctanone
Body's iterative force-field computer program has been used to calculate strain energies in cyclooctanone (I). 348 MHZ 1H NMR spectra of (I) have been investigated over the temperature range of 25° to -160°C. Two conformation processes affect the 1H NMR spectrum of (I). Iterative force-field calculations on the conformations and conformational interconversion paths of ...
متن کاملA New Colorimetric Azo-azomethine Probe for Fluoride Ion Detection Based on the Proton Transfer Signaling Mode: Real-life Applications
Four novel receptors were designed and synthesized for colorimetric detection of F− ions. The introduction of four electron withdrawing groups into the backbone of the receptors makes the two phenolic groups efficient hydrogen bonding sites. The binding properties of receptors with anions were examined for the first time by UV–Vis, 1H NMR and fluorescence spectroscopies. The addition of F− resu...
متن کاملDetection of Sesquiterpene Lactones in Ten Artemisia Species Population of Khorasan Provinces
Objective During the last three decades sesquiterpenoid lactones have emerged as one of the largest groups of plant products with over 3000 naturally occurring substances known. The genus Artemisia characteristically contains this biologically active type of secondary metabolites. With respect to increasing interest in the cytotoxic, antibiotic, phototoxic and antineoplastic activities of sesq...
متن کامل